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"The right test, on the right specimen, collected at the right time, is essential for reliable diagnosis" Dr Prashant Goyal

Typhoid RT-PCR Test: Breaking Barriers in Typhoid Diagnosis

  Typhoid fever , caused by a gram negative bacteria Salmonella typhi , remains a significant global health concern. Accurate and timely diagnosis of typhoid fever is crucial for appropriate patient management and effective control of the disease. Current methods of diagnosis include Serology based tests like the convenonal WIDAL test and Rapid Card Tests (Typhidot Or Enterocheck) and the Blood Culture test. In recent years, molecular testing techniques, particularly Reverse Transcription Polymerase Chain Reaction (RT-PCR), have emerged as a significant advancement in typhoid diagnosis.  The Limitations of Traditional Methods:  The Widal test , based on the detection of antibodies against S. Typhi and S. paratyphi antigens, has long been used for typhoid diagnosis. However, it has several limitations, including cross-reactivity, lack of specificity, unable to diagnose in early stage (first week) and the inability to differentiate between current and past infections. Serol...

Ways To Maintain A Health in Rainy Season

Rainy (Monsoon) season are known to make the climate pleasant and adds scenic beauty to the environment. It gives a new life to the earth. However, monsoon also brings along numerous diseases (esp. food borne and mosquito-borne diseases) due to harmful viruses, bacteria and fungus. Common cold, Flu, Stomach Infection, Diarrhoea, Malaria, Dengue, Typhoid, Chikungunya, Viral fever and Allergy are some of the diseases which make it to the top of the list. The common victims are children and people with low immunity.   Enjoy the monsoon rains the healthy way by eating good food and following certain following precautionary measures.   Eat a healthy, balanced diet to keep you fit. Avoid junk food, street food and pre-cut fruits, especially from the roadside stalls. Eat steamed salads instead of raw vegetables. Thoroughly scrub fruits and vegetables under running water before consuming. Better to avoid milk, and chose other milk-products like yogurt, curd, etc. Include more Vitami...

Dengue Fever in Pregnancy

Dengue fever is a viral disease caused by any of four closely related serotypes of flavivirus (RNA virus). Aedes mosquito particularly aedes aegyptii is a vector transmitting it to human beings. Most parts of India are dengue epidemis because of overcrowding and poor sanitation and civic bodies. As cases of adult dengue fever increases after monsoons it also affects pregnant females. The clinical manifestations, treatment and outcome of dengue in pregnant women are similar to those of nonpregnant patients. Few areas of concern shall be briefly touched in this article. Classical dengue fever is characterized by sudden high fever, severe headache, retro-orbital pain and non specific body aches. Sometimes, ecchymosis or rash develop or bleeding symptoms appear. Dengue infections can sometimes also accompany potentially fatal complications that can cause shock, bleeding or organ damage.  Hence, a pregnant female should always be worked for suspected dengue infection. Misdiag...