Rapid molecular diagnostics have transformed the diagnosis and management of tuberculosis (TB). CBNAAT (Cartridge-Based Nucleic Acid Amplification Test) and MTB PCR enable early detection of Mycobacterium tuberculosis (MTB) and provide rapid information on drug resistance. Traditionally, most attention has focused on detecting R ifampicin (RIF) resistance, as it is considered an important marker for multidrug-resistant tuberculosis (MDR-TB). However, limiting resistance detection to rifampicin alone may overlook another clinically significant challenge - Isoniazid (INH) resistance. Isoniazid is one of the most effective first-line anti-tubercular drugs and plays a major role in early bacterial killing during treatment. Resistance to INH can occur independently (INH monoresistance) or together with rifampicin resistance. When INH resistance remains undetected, patients may continue receiving standard treatment regimens that are less effective for their infection. The clinical ...