Accuprobe Awareness

Thrombosis with Thrombocytopenia Syndrome (TTS) is a rare but severe clotting disorder. While TTS is rare, certain COVID-19 vaccines , particularly those based on adenoviral vectors, have been associated with an increased risk of TTS events in some individuals. This syndrome involves blood clot formation (thrombosis) accompanied by low platelet levels (thrombocytopenia), often occurring within a few weeks of vaccination. While the occurrence of TTS post-vaccination is exceedingly rare, it sparked global concern and led to thorough investigations by health authorities. The exact mechanism behind TTS is still under investigation, but it is believed to involve an immune-mediated response triggered by the vaccine, leading to the formation of antibodies that activate platelets, culminating in clot formation and platelet consumption. Symptoms of TTS can vary depending on the location and severity of blood clots. Common signs may include: Severe headaches or migraines Abdominal pain or swell...

Serum protein electrophoresis (SPEP) is a valuable diagnostic tool used not only in the detection and monitoring of multiple myeloma but also in various other medical conditions. Here are some examples: Monoclonal Gammopathy of Undetermined Significance (MGUS): SPEP is crucial in diagnosing MGUS, a condition where there is a presence of abnormal proteins (monoclonal proteins or M-proteins) in the blood, which may progress to multiple myeloma or related disorders over time. Amyloidosis: SPEP can help identify abnormal proteins associated with amyloidosis, a condition characterized by the deposition of abnormal proteins in various tissues and organs, leading to organ dysfunction. Waldenström Macroglobulinemia: In this condition, there is an overproduction of a specific type of abnormal protein called IgM. SPEP can help in detecting the presence of IgM in the blood. Chronic Inflammatory Conditions: Chronic inflammatory diseases such as rheumatoid arthritis, systemic lupus erythematosus...

The LE (Lupus Erythematosus) cells test , has been utilized for decades in the diagnosis of systemic lupus erythematosus (SLE) and other autoimmune conditions. However, amidst advances in medical technology and understanding, questions have arisen regarding the relevance and reliability of this test in contemporary clinical practice. The LE cells test involves examining a patient's blood sample under a microscope for the presence of "LE cells," which are white blood cells that have engulfed the nucleus of another cell. The rationale behind its use lies in the observation that LE cells are often found in the blood of individuals with SLE due to the presence of autoantibodies targeting components of the cell nucleus. For decades, the LE cells test served as a cornerstone in the diagnosis of SLE and other autoimmune diseases. It provided clinicians with a valuable tool for confirming suspicions raised by clinical symptoms and other laboratory findings. However, the landscap...